Nick, Yes, that is possible. The uSeg EPG classification using IP address corresponds to the IP of the NIC. So, each NIC ca be placed in a separate uSeg EPG using the IP address attribute. Another idea is to use MAC based EPG where each NIC would have a unique mac-address assign it to uSeg EPG. For your HyperV question, Microsoft SCVMM uSeg support was introduced in Brazos release which shipped in December 2015. Brazos supports ACI uSeg for Hyper-V host using IP address attribute as well as VM attributes.